Computer simulations of consecutive radiofrequency pulses applied at the same point during cardiac catheter ablation: Implications for lesion size and risk of overheating. (June 2022)

• Record Type: Journal Article
• Authors: Sánchez-Muñoz, Eugenio J; Berjano, Enrique; González-Suárez, Ana
• Is Part Of: Computer methods and programs in biomedicine. Volume 220(2022)
• Publication Date: 2022-06
• Subjects: In-silico study -- Lesion overlapping -- Repeated application -- RF ablation; Medicine -- Computer programs -- Periodicals; Biology -- Computer programs -- Periodicals; Computers -- Periodicals; Medicine -- Periodicals; Médecine -- Logiciels -- Périodiques; Biologie -- Logiciels -- Périodiques; Biology -- Computer programs; Medicine -- Computer programs; Periodicals; Electronic journals; 610.28
• DOI: 10.1016/j.cmpb.2022.106817
• Languages: English
• ISSNs: 0169-2607

Abstract

Highlights: Computer modeling study assessing repeated RF power pulses on myocardium. The second RF pulse increases lesion depth by 1 − 1.5 mm more than a single pulse. The second pulse may lead to higher temperatures than a single pulse (up to 17 ºC). Shortening the time between pulses means larger lesions and maximum temperature. Abstract: Background and objectives: To study temperature distribution and lesion size during two repeated radiofrequency (RF) pulses applied at the same point in the context of RF cardiac ablation (RFCA). Methods: An in-silico RFCA model accounting for reversible and irreversible changes in myocardium electrical properties due to RF-induced heating. Arrhenius damage model to estimate lesion size during the application of two 20 W pulses at intervals (INT) of from 5 to 70 s. We considered two pulse durations: 20 s and 30 s. Results: INT has a significant effect on lesion size and maximum tissue temperature (TMAX). The shorter the INT the greater the increase in lesion size after the second pulse but also the greater the TMAX. If the second pulse is applied almost immediately (INT=5 s), depth increases 1.4 mm and 1.5 mm for pulses of 20 s and 30 s, respectively. If INT is longer than 30 s it increases 1.1 mm and 1.3 mm for pulses of 20 s and 30 s, respectively. While a single 20 s pulse causes TMAX =79 ºC, a second pulse produces values of from 92 to 96 ºC (the higher the temperature the shorter the INT). For 30 s pulses, TMAX =93 ºC for a single pulse, and varied from 98 to 104 ºC for a second pulse. Conclusions: Applying a second RF pulse at the same ablation site increases lesion depth by 1 − 1.5 mm more than a single pulse and could lead to higher temperatures (up to 17 ºC). Both lesion depth and maximum tissue temperature increased at shorter inter-pulse intervals, which could cause clinical complications from overheating such as steam pops.