Synthesis and biological activity of structurally diverse phthalazine derivatives: A systematic review. Issue 18 (15th September 2019)

• Record Type: Journal Article
• Authors: Sangshetti, Jaiprakash; Pathan, Shahebaaz K.; Patil, Rajesh; Akber Ansari, Siddique; Chhajed, Santosh; Arote, Rohidas; Shinde, Devanand B.
• Is Part Of: Bioorganic & medicinal chemistry. Volume 27:Issue 18(2019)
• Page Start: 3979
• Page End: 3997
• Publication Date: 2019-09-15
• Subjects: Bioorganic chemistry -- Periodicals; Pharmaceutical chemistry -- Periodicals; Biochemistry -- Periodicals; Chemistry, Clinical -- Periodicals; Chemistry, Organic -- Periodicals; Chimie bio-organique -- Périodiques; Chimie pharmaceutique -- Périodiques; 615.19
• DOI: 10.1016/j.bmc.2019.07.050
• Languages: English
• ISSNs: 0968-0896

Abstract

Graphical abstract: Abstract: Phthalazine, a structurally and pharmacologically versatile nitrogen-containing heterocycle, has gained more attention from medicinal chemists in the design and synthesis of novel drugs owing to its pharmacological potential. In particular, phthalazine scaffold appeared as a pharmacophoric feature numerous drugs exhibiting pharmacological activities, in particular, antidiabetic, anticancer, antihypertensive, antithrombotic, anti-inflammatory, analgesic, antidepressant and antimicrobial activities. This review presents a summary of updated and detailed information on phthalazine as illustrated in both patented and non-patented literature. The reported literature have described the optimal pharmacological characteristics of phthalazine derivatives and highlighted the applicability of phthalazine, as potent scaffold in drug discovery.