Biodegradable N, O-carboxymethyl chitosan/oxidized regenerated cellulose composite gauze as a barrier for preventing postoperative adhesion. (1st March 2019)

• Record Type: Journal Article
• Authors: Cheng, Feng; Wu, Yadong; Li, Hongbin; Yan, Tingsheng; Wei, Xinjing; Wu, Guangyu; He, Jinmei; Huang, Yudong
• Is Part Of: Carbohydrate polymers. Volume 207(2019)
• Page Start: 180
• Page End: 190
• Publication Date: 2019-03-01
• Subjects: N, O-Carboxymethyl chitosan -- Oxidized regenerated cellulose -- N, O-CS/ORC composite gauze -- Barrier -- Postoperative adhesion; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2018.10.077
• Languages: English
• ISSNs: 0144-8617

Abstract

Graphical abstract: Highlights: The N, O-CS/ORC composite gauze can be biodegraded, no toxicity to normal cells. The composite gauze has excellent antimicrobial functionality. The composite gauze also has exhibits excellent hemostatic. It could set as an effective barrier to prevent the postsurgical adhesion. Abstract: Tissue adhesion is one of the most common complications after surgery (especially after abdominal surgery), causing notable influences after the damaged tissue has healed. A physical barrier placed between the wound site and the adjacent tissues is a convenient and highly effective technique to minimize or prevent abdominal adhesions. In this work, the N, O -carboxymethyl chitosan/oxidized regenerated cellulose ( N, O-CS/ORC ) composite gauze was prepared. The N, O-CS/ORC composite gauze is degradable; in addition, the gauze exhibits excellent antimicrobial functionality against S. aureus and E. coli bacteria. Moreover, the notable hemostatic efficacy of the N, O-CS/ORC composite gauze was confirmed in rabbit livers/ears as models. The results showed that the N, O-CS/ORC composite gauze is nontoxic toward normal cells and can restrain the adhesion of fibroblast cells, thereby indicating its potential use in preventing tissue adhesion. In addition, the rat models for abdominal defect-cecum abrasion were used to evaluate the efficacy of N, O-CS/ORC composite gauze in preventing tissue adhesions after surgery. The results indicated that the N, O-CS/ORC composite gauze can significantly prevent postsurgical peritoneal adhesions. Finally, the potential anti-adhesion mechanism of the N, O-CS/ORC composite gauze, which may attribute to the combination of barrier function and instinct activity of N, O-CS and ORC, was investigated.