Adenovirus vectors activate Vδ2+ γδT cells in a type I interferon‐, TNF‐, and IL‐18‐dependent manner. Issue 5 (17th January 2022)

• Record Type: Journal Article
• Authors: Provine, Nicholas M.; Amini, Ali; Garner, Lucy C.; FitzPatrick, Michael E.B.; Dold, Christina; Silva Reyes, Laura; Chinnakannan, Senthil; Oguti, Blanche; Raymond, Meriel; Troise, Fulvia; Capone, Stefania; Folgori, Antonella; Barnes, Eleanor; Rollier, Christine S.; Pollard, Andrew J.; Klenerman, Paul
• Is Part Of: European journal of immunology. Volume 52:Issue 5(2022)
• Page Start: 835
• Page End: 837
• Publication Date: 2022-01-17
• Subjects: Immunology -- Periodicals; 616.079
• DOI: 10.1002/eji.202149367
• Languages: English
• ISSNs: 0014-2980

Abstract

Abstract : Vδ2 + γδT cells are unconventional T cells that can be activated by cytokines without TCR signaling. Adenovirus vaccine vectors activated Vδ2 + γδT cells in an interleukin 18‐, TNF‐, and type I interferon‐dependent manner. This stimulatory capacity was associated with adenovirus vectors of non‐species C origin, including the ChAdOx1 vaccine platform.