Diabetic nephropathy ameliorated in patients with normal home blood pressure compared to those with isolated high home systolic blood pressure: A 5-year prospective cohort study among patients with type 2 diabetes mellitus. (19th May 2022)

• Record Type: Journal Article
• Authors: Kitagawa, Nobuko; Ushigome, Emi; Kitagawa, Noriyuki; Ushigome, Hidetaka; Yokota, Isao; Nakanishi, Naoko; Hamaguchi, Masahide; Asano, Mai; Yamazaki, Masahiro; Fukui, Michiaki
• Is Part Of: Diabetes & vascular disease research. Volume 19:Number 3(2022)
• Publication Date: 2022-05-19
• Subjects: albuminuria -- diabetes mellitus -- diabetic nephropathy -- IH-home SBP -- normal home BP; Diabetic angiopathies -- Periodicals; 616.462005
• DOI: 10.1177/14791641221098193
• Languages: English
• ISSNs: 1479-1641

Abstract

Background: Using normal home blood pressure (home BP) as a reference, isolated high home systolic blood pressure (IH-home SBP) increases the risk of diabetic nephropathy. However, whether diabetic nephropathy would improve among diabetic patients without IH-home SBP has not been previously assessed. Methods: This prospective 5-year cohort study of 264 patients with moderate or severe albuminuria investigated the effect of IH-home SBP or normal home BP on the risk of diabetic nephropathy in patients with type 2 diabetes mellitus. Improvement of diabetic nephropathy was defined as remission or regression from moderate or severe albuminuria to normal or mildly increased albuminuria. Results: Improvement of diabetic nephropathy was shown in 59 out of 264 patients during 5 years. The adjusted odds ratio (95% confidence interval) of normal home BP for improving diabetic nephropathy was 2.52 (1.01–5.99, p = 0.05). Conclusion: Normal home BP had relation to an improvement in diabetic nephropathy among type 2 diabetic patients with moderate and severe increased albuminuria in the observation period of 5 years. Good home BP control might be valuable to ameliorate diabetic nephropathy.