Infantile nephrotic syndrome secondary to cytomegalovirus infection in a 7-month-old girl: resolution with ganciclovir. (3rd April 2021)

• Record Type: Journal Article
• Authors: Kaur, Jasleen; Deepthi, Bobbity; Dhull, Rachita Singh; Faruq, M. D.; Saha, Abhijeet
• Is Part Of: Paediatrics and international child health. Volume 41:Number 2(2021)
• Page Start: 162
• Page End: 165
• Publication Date: 2021-04-03
• Subjects: Infant -- nephrotic syndrome -- CMV -- Ganciclovir; Pediatrics -- Developing countries -- Periodicals; Children -- Health and hygiene -- Developing countries -- Periodicals; Children -- Diseases -- Developing countries -- Periodicals; 618.920009172405
• DOI: 10.1080/20469047.2020.1823176
• Languages: English
• ISSNs: 2046-9047

Abstract

ABSTRACT: Infantile nephrotic syndrome is a rare disorder which is frequently caused by genetic defects. A 7-month-old girl presented with fever, loose stools and anasarca and was diagnosed with nephrotic syndrome. Work-up for a genetic cause was negative. Cytomegalovirus polymerase chain reaction (CMV PCR) was positive and the infant was treated with ganciclovir for 6 weeks, followed by valganciclovir for 10 weeks. All symptoms resolved within 2 weeks of commencing treatment and she attained complete remission within 4 weeks. CMV PCR was negative within 4 weeks of antiviral therapy. At 18 months follow-up she remained well. Appropriate treatment of infantile nephrotic syndrome secondary to CMV should result in recovery.