Association between radiation dose to organs at risk and acute patient reported outcome during radiation treatment for head and neck cancers. Issue 6 (31st March 2022)

• Record Type: Journal Article
• Authors: Arbab, Mona; Chen, Yu‐Hui; Tishler, Roy B.; Gunasti, Lauren; Glass, Jason; Fugazzotto, Jo Ann; Killoran, Joseph H.; Sethi, Rosh; Rettig, Eleni; Annino, Donald; Goguen, Laura; Uppaluri, Ravindra; Hsu, Carolyn; Burke, Elaine; Hanna, Glenn J.; Lorch, Jochen; Haddad, Robert I.; Margalit, Danielle N.; Schoenfeld, Jonathan D.
• Is Part Of: Head & neck. Volume 44:Issue 6(2022)
• Page Start: 1442
• Page End: 1452
• Publication Date: 2022-03-31
• Subjects: head and neck cancers -- organs at risk -- patient reported outcome -- radiation dose; Head -- Diseases -- Periodicals; Neck -- Diseases -- Periodicals; Head -- Periodicals; Neck -- Periodicals; Face -- Periodicals; 617.51059
• DOI: 10.1002/hed.27031
• Languages: English
• ISSNs: 1043-3074

Abstract

Abstract: Background: Associations between patient‐reported outcomes and dose to organs at risk (OARs) may promote management and guide future investigations. Methods: We retrospectively evaluated PROs and OAR dose in head and neck (H&N) cancer. Results: In 169 patients, we identified weak associations between: "Difficulty swallowing/chewing" and increased mean RT dose to the oral cavity, larynx, pharyngeal constrictor muscles (PCM) and contralateral parotid; "choking/coughing" and larynx mean dose; "problems with mucus in mouth and throat" and oral cavity, contralateral parotid mean dose and parotid V30, contralateral submandibular gland and PCM mean dose; "difficulty with voice/speech" and oral cavity, contralateral parotid, contralateral submandibular gland and larynx mean dose; and "dry mouth" and ipsilateral submandibular gland, oral cavity and PCM mean dose. Conclusion: We identified weak associations between PRO and dose to OARs—these data can guide on treatment management, patient counseling, and serve as a baseline for future investigations.