Redox-neutral dehydrogenative cross-coupling of alcohols and amines enabled by nickel catalysis. Issue 6 (15th February 2022)

• Record Type: Journal Article
• Authors: Yan, Zijuan; Liu, Feipeng; Wang, Xuchao; Qiang, Qing; Li, Yongjie; Zhang, Yao; Rong, Zi-Qiang
• Is Part Of: Organic chemistry frontiers. Volume 9:Issue 6(2022)
• Page Start: 1703
• Page End: 1710
• Publication Date: 2022-02-15
• Subjects: Chemistry, Organic -- Periodicals; 547.005
• DOI: 10.1039/d2qo00004k
• Languages: English
• ISSNs: 2052-4110

Abstract

Abstract : A facile and straightforward synthetic method for the construction of amides via redox-neutral Ni/NHC-catalyzed dehydrogenative cross-coupling of alcohols and amines has been developed. Abstract : Presented herein is a facile and straightforward synthetic method for the construction of amides via Ni/NHC-catalyzed amidation of alcohols with amines. The strategy exhibits various advantages over existing methods, including base metal catalysis, commercially available catalyst, removal of oxidant, good yields (up to 95%), good functional group tolerance and substrate generality. Moreover, the nature of the reaction was revealed by NMR spectroscopy and isolation of intermediates.