Sonochemical synthesis and anti-gastric cancer activity of a Cu(II) coordination polymer. Issue 11 (2nd November 2021)

• Record Type: Journal Article
• Authors: Huang, Bo; Cui, De-Jun; Zhang, Man-Man; Yan, Fang; Zhao, Xun; Yang, Liu-Chan; Ren, Ying
• Is Part Of: Inorganic and nano-metal chemistry. Volume 51:Issue 11(2021)
• Page Start: 1512
• Page End: 1518
• Publication Date: 2021-11-02
• Subjects: Coordination polymer -- cancer cell -- nanostructure -- western blot; Inorganic compounds -- Synthesis -- Periodicals; Nanostructured materials -- Periodicals; Reactivity (Chemistry) -- Periodicals; Inorganic compounds -- Synthesis; Nanostructured materials; Reactivity (Chemistry); Periodicals; 546
• DOI: Https://www.tandfonline.com/doi/10.1080/24701556.2020.1841236
• Languages: English
• ISSNs: 2470-1556

Abstract

Abstract: Via applying the mixed-ligand approach, a new Cu(II)-bearing coordination polymer (CP) with the chemical formula of [Cu(1, 4-chdc)(L)(H2 O)]n (1, (1, 4-H2 chdc = 1, 4-cyclohexanedicarboxylic acid, L = 2-(4-fluorophenyl)-1H-imidazo[4, 5-f][1, 10]phenanthroline) has been successfully prepared under hydrothermal condition. The single-crystal X-ray diffraction study shows that CP 1 shows a 1D chain-like structure which is further extended into a 2D supramolecular network via the H-bond interactions. Furthermore, a sonochemical treatment method was applied to produce the nanosized 1 with the size distribution around 200 nm. To detect the cell proliferation of MGC-803 (human gastric cancer cell lines) after treated with nano 1, the Cell Counting Kit-8 (CCK-8) assay was performed in this experiment. Besides, the MGC-803 cell apoptosis was determined by Annexin V-FITC/PI (FITC = fluorescein isothiocyanate, PI = propidium iodide) apoptosis detection kit in flow cytometer and western blot after treated with nano 1 . GRAPHICAL ABSTRACT: A new Cu(II)-bearing coordination polymer has been prepared under hydrothermal conditions. A sonochemical treatment method was applied to produce the nanosized 1 with the size distribution around 200 nm. The anti-cancer activity of nano 1 has been evaluated via the Cell Counting Kit-8 (CCK-8) assay and Annexin V-FITC/PI.