Two Co(II) coordination polymers: crystal structures and anti-ovarian cancer activity by inducing the ROS genes expression. Issue 4 (14th March 2022)

• Record Type: Journal Article
• Authors: Yang, Dong-Mei; Huang, Li-Hong; Xia, Qiong; Li, Ai-Ling; Chen, Yu
• Is Part Of: Inorganic and nano-metal chemistry. Volume 52:Issue 4(2022)
• Page Start: 608
• Page End: 613
• Publication Date: 2022-03-14
• Subjects: Coordination complexes -- anti-ovarian cancer -- RT-PCR -- ROS; Inorganic compounds -- Synthesis -- Periodicals; Nanostructured materials -- Periodicals; Reactivity (Chemistry) -- Periodicals; Inorganic compounds -- Synthesis; Nanostructured materials; Reactivity (Chemistry); Periodicals; 546
• DOI: Https://www.tandfonline.com/doi/10.1080/24701556.2021.1916759
• Languages: English
• ISSNs: 2470-1556

Abstract

Abstract: Two new unsymmetrical ligands, namely, 2-(pyridin-3-yl)-5-(quinolin-2-yl)-1, 3, 4-oxadiazole (L1) and 2-(pyridin-4-yl)-5-(quinolin-2-yl)-1, 3, 4-oxadiazole (L2), have been synthesized and their self-assembly reactions with Co(NO3 )2 and Co(ClO4 )2 have been investigated for the rational construction of coordination polymers (CPs). It was found that the counter-anion plays an important role in the structural assemblies. Their anti-ovarian cancer activity was evaluated and the related mechanism was explored at the same time. Firstly, the proliferation of the ovarian cancer cells was measured with CCK-8 detection kit. Then, the real time RT-PCR was used to evaluate the relative expression levels of the ROS related genes in the ovarian cancer cells after compounds treatment.