Dendrobium huoshanense polysaccharide regionally regulates intestinal mucosal barrier function and intestinal microbiota in mice. (15th February 2019)

• Record Type: Journal Article
• Authors: Xie, Song-Zi; Liu, Bing; Ye, Hui-Yu; Li, Qiang-Ming; Pan, Li-Hua; Zha, Xue-Qiang; Liu, Jian; Duan, Jun; Luo, Jian-Ping
• Is Part Of: Carbohydrate polymers. Volume 206(2019)
• Page Start: 149
• Page End: 162
• Publication Date: 2019-02-15
• Subjects: Dendrobium huoshanense -- Polysaccharides -- Intestinal barrier function -- Microbiota composition -- Intestinal physiological status -- Systemic immune response; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2018.11.002
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: D. huoshanense polysaccharide (GXG) altered the intestinal physiological status. GXG could enhance the mucosal barrier functions in different intestinal regions. GXG differently regulated microbiota composition along the intestinal tract. Abstract: The present study investigated the effects of a homogeneous Dendrobium huoshanense polysaccharide (GXG) on mucosal barrier function and microbiota composition in different intestinal regions of mice. Results exhibited, besides changing the intestinal physiological status, orally administrated GXG could improve the intestinal physical barrier function by modulating mucosal structures and up-regulating the expression of tight junction proteins, reinforce the intestinal biochemical barrier function by elevating the expression and secretion of mucin-2, β-defensins and sIgA, and regulate the intestinal immunological barrier function by stimulating the production of cytokines and the functional development of immune cells. Simultaneously, GXG could differentially impact the composition and metabolism of microbiota along intestinal tract. In addition, the immune response in spleen and peripheral blood were effectively regulated by GXG. These results indicated that GXG might be used as functional agent to improve host health.