Pain and functional disability amongst adults with moderate and severe haemophilia from the Irish personalised approach to the treatment of haemophilia (iPATH) study. (30th March 2022)

• Record Type: Journal Article
• Authors: Kennedy, Megan; O' Mahony, Brian; Roche, Sheila; McGowan, Mark; Singleton, Evelyn; Ryan, Kevin; O' Connell, Niamh M.; Pipe, Steven W.; Lavin, Michelle; O' Donnell, James S.; Turecek, Peter L.; Gormley, John
• Is Part Of: European journal of haematology. Volume 108:Number 6(2022)
• Page Start: 518
• Page End: 527
• Publication Date: 2022-03-30
• Subjects: function -- haemophilia -- pain -- physical activity -- prophylaxis; Hematology -- Periodicals; Blood -- Diseases -- Periodicals; Blood -- Periodicals; 616.15005
• DOI: 10.1111/ejh.13763
• Languages: English
• ISSNs: 0902-4441

Abstract

Abstract: Objectives: To establish the prevalence of pain and functional disability in Irish adults with moderate and severe haemophilia, and to examine demographic and lifestyle influences. Methods: Males ≥18 years with moderate or severe haemophilia participated. Pain and function were examined using the PROBE questionnaire. Results: Of 49 participants [median age 44 (IQR 32, 52) years], most had severe haemophilia (Factor VIII = 30; Factor IX = 13) and were on regular prophylaxis (88%). Those with moderate haemophilia (Factor VIII = 5; Factor IX = 1) treated on demand (12%). Acute (72%) and chronic pain (71%), functional difficulties (58%), and analgesic requirements (92%) were prevalent. Age was significantly associated with more advanced haemophilic arthropathy ( p = .002), chronic pain ( p = .029) and functional difficulties ( p = .036). Adults who reported chronic pain commenced prophylaxis significantly later in life [32 (20, 51) vs. 8 (1, 23) years; p = .004]. Physical activity was significantly lower in those with functional difficulties ( p < .05). A disparity between self‐perceived 'target joints' and clinically defined target joints was also identified (76% vs. 23%). Conclusion: Haemophilic arthropathy, pain and functional disability were prevalent amongst Irish adults with moderate and severe haemophilia. Age‐dependent lifestyle, analgesic and treatment influences on pain and function warrant further investigation.