Therapeutic proton beams: LET, RBE and microdosimetric spectra with gas and silicon detectors. (August 2020)

• Record Type: Journal Article
• Authors: Colautti, P.; Bianchi, A.; Selva, A.; Bortot, D.; Mazzucconi, D.; Pola, A.; Agosteo, S.; Petringa, G.; Cirrone, G.A.P.; Conte, V.
• Is Part Of: Radiation measurements. Volume 136(2020:May)
• Publication Date: 2020-08
• Subjects: Microdosimetry -- Proton therapy -- Proton RBE -- Mini-TEPC -- Silicon telescope detector -- MicroPlus Bridge detector; Nuclear emulsions -- Periodicals; Particle tracks (Nuclear physics) -- Periodicals; Thermoluminescence -- Periodicals; Cosmic rays -- Periodicals; Radiation -- Measurement -- Periodicals; Radiometry -- Periodicals; Radiation Monitoring -- Periodicals; Émulsions nucléaires -- Périodiques; Particules (Physique nucléaire) -- Traces -- Périodiques; Thermoluminescence -- Périodiques; Rayonnement cosmique -- Périodiques; Radiométrie -- Périodiques; 539.77
• DOI: 10.1016/j.radmeas.2020.106386
• Languages: English
• ISSNs: 1350-4487

Abstract

Abstract: A sealed mini-TEPC able to work in gas-steady modality, a monolithic silicon device composed by a matrix of micrometric cylindrical diodes and a residual energy measurement stage and the silicon MicroPlus Bridge detector were used to perform microdosimetric measurements at the 62 MeV proton clinical SOBP of CATANA at the Southern National Laboratories of INFN (LNS – INFN, Catania, Italy). Measurements were taken at the same different positions in a PMMA phantom, in order to analyse the detector response differences. Finally, a weighting function was applied to the spectra to see if the microdosimetric detectors are able to monitor RBE data for glioma cells (U87) irradiated at six positions along the same modulated 62-MeV proton beam. The results obtained with the three microdosimeters are compared and discussed. Highlights: Mini-TEPC, thin and thick silicon detectors have measured at the CATANA proton facility. Mini-TEPC and thick silicon detectors can monitor with good accuracy proton RBE values. Thin silicon detectors can monitor proton RBE values only in the distal edge.