ZnO/Nanocarbons‐Modified Fibrous Scaffolds for Stem Cell‐Based Osteogenic Differentiation. Issue 38 (19th August 2020)

• Record Type: Journal Article
• Authors: Xia, Yi; Fan, Xin; Yang, Hua; Li, Ling; He, Chao; Cheng, Chong; Haag, Rainer
• Is Part Of: Small. Volume 16:Issue 38(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-08-19
• Subjects: anti‐infective surfaces -- carbon nanomaterials -- metal–organic frameworks -- nanostructured fibrous scaffolds -- osteogenic surfaces -- stem cells; Nanotechnology -- Periodicals; Nanoparticles -- Periodicals; Microtechnology -- Periodicals; 620.5
• DOI: 10.1002/smll.202003010
• Languages: English
• ISSNs: 1613-6810

Abstract

Abstract: Currently, mesenchymal stem cells (MSCs)‐based therapies for bone regeneration and treatments have gained significant attention in clinical research. Though many chemical and physical cues which influence the osteogenic differentiation of MSCs have been explored, scaffolds combining the benefits of Zn 2+ ions and unique nanostructures may become an ideal interface to enhance osteogenic and anti‐infective capabilities simultaneously. In this work, motivated by the enormous advantages of Zn‐based metal–organic framework‐derived nanocarbons, C‐ZnO nanocarbons‐modified fibrous scaffolds for stem cell‐based osteogenic differentiation are constructed. The modified scaffolds show enhanced expression of alkaline phosphatase, bone sialoprotein, vinculin, and a larger cell spreading area. Meanwhile, the caging of ZnO nanoparticles can allow the slow release of Zn 2+ ions, which not only activate various signaling pathways to guide osteogenic differentiation but also prevent the potential bacterial infection of implantable scaffolds. Overall, this study may provide new insight for designing stem cell‐based nanostructured fibrous scaffolds with simultaneously enhanced osteogenic and anti‐infective capabilities. Abstract : ZnO/nanocarbons‐modified fibrous scaffolds are fabricated for mesenchymal stem cells‐based osteogenic differentiation. The scaffolds show enhanced expression of alkaline phosphatase, bone sialoprotein, vinculin, and larger cell‐spreading area. The combined benefits of unique nanostructures and Zn 2+ ions releasing not only endow the scaffolds with simultaneously enhanced osteogenic and anti‐infective capabilities but also provide new insights for designing stem cells‐regeneration scaffolds.