Cortical lesion hotspots and association of subpial lesions with disability in multiple sclerosis. (August 2022)

• Record Type: Journal Article
• Authors: Beck, Erin S; Maranzano, Josefina; Luciano, Nicholas J; Parvathaneni, Prasanna; Filippini, Stefano; Morrison, Mark; Suto, Daniel J; Wu, Tianxia; van Gelderen, Peter; de Zwart, Jacco A; Antel, Samson; Fetco, Dumitru; Ohayon, Joan; Andrada, Frances; Mina, Yair; Thomas, Chevaz; Jacobson, Steve; Duyn, Jeff; Cortese, Irene; Narayanan, Sridar; Nair, Govind; Sati, Pascal; Reich, Daniel S
• Is Part Of: Multiple sclerosis. Volume 28:Number 9(2022)
• Page Start: 1351
• Page End: 1363
• Publication Date: 2022-08
• Subjects: Multiple sclerosis -- cortical lesions -- 7 tesla MRI; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585211069167
• Languages: English
• ISSNs: 1352-4585

Abstract

Background: Dramatic improvements in visualization of cortical (especially subpial) multiple sclerosis (MS) lesions allow assessment of impact on clinical course. Objective: Characterize cortical lesions by 7 tesla (T) T2 * -/T1 -weighted magnetic resonance imaging (MRI); determine relationship with other MS pathology and contribution to disability. Methods: Sixty-four adults with MS (45 relapsing–remitting/19 progressive) underwent 3 T brain/spine MRI, 7 T brain MRI, and clinical testing. Results: Cortical lesions were found in 94% (progressive: median 56/range 2–203; relapsing–remitting: 15/0–168; p = 0.004). Lesion distribution across 50 cortical regions was nonuniform ( p = 0.006), with highest lesion burden in supplementary motor cortex and highest prevalence in superior frontal gyrus. Leukocortical and white matter lesion volumes were strongly correlated ( r = 0.58, p < 0.0001), while subpial and white matter lesion volumes were moderately correlated ( r = 0.30, p = 0.002). Leukocortical ( p = 0.02) but not subpial lesions ( p = 0.40) were correlated with paramagnetic rim lesions; both were correlated with spinal cord lesions ( p = 0.01). Cortical lesion volumes (total and subtypes) were correlated with expanded disability status scale, 25-foot timed walk, nine-hole peg test, and symbol digit modality test scores. Conclusion: Cortical lesions are highly prevalent and are associated with disability and progressive disease. Subpial lesion burden is not strongly correlated with white matter lesions, suggesting differences in inflammation and repair mechanisms.