The risk of infections for multiple sclerosis and neuromyelitis optica spectrum disorder disease-modifying treatments: Eighth European Committee for Treatment and Research in Multiple Sclerosis Focused Workshop Review. April 2021. (August 2022)

• Record Type: Journal Article
• Authors: Tur, Carmen; Dubessy, Anne-Laure; Otero-Romero, Susana; Amato, Maria Pia; Derfuss, Tobias; Di Pauli, Franziska; Iacobaeus, Ellen; Mycko, Marcin; Abboud, Hesham; Achiron, Anat; Bellinvia, Angelo; Boyko, Alexey; Casanova, Jean-Laurent; Clifford, David; Dobson, Ruth; Farez, Mauricio F; Filippi, Massimo; Fitzgerald, Kathryn C; Fonderico, Mattia; Gouider, Riadh; Hacohen, Yael; Hellwig, Kerstin; Hemmer, Bernhard; Kappos, Ludwig; Ladeira, Filipa; Lebrun-Frénay, Christine; Louapre, Céline; Magyari, Melinda; Mehling, Matthias; Oreja-Guevara, Celia; Pandit, Lekha; Papeix, Caroline; Piehl, Fredrik; Portaccio, Emilio; Ruiz-Camps, Isabel; Selmaj, Krzysztof; Simpson-Yap, Steve; Siva, Aksel; Sorensen, Per Soelberg; Sormani, Maria Pia; Trojano, Maria; Vaknin-Dembinsky, Adi; Vukusic, Sandra; Weinshenker, Brian; Wiendl, Heinz; Winkelmann, Alexander; Zuluaga Rodas, María Isabel; Tintoré, Mar; Stankoff, Bruno;
• Is Part Of: Multiple sclerosis. Volume 28:Number 9(2022)
• Page Start: 1424
• Page End: 1456
• Publication Date: 2022-08
• Subjects: Multiple sclerosis -- neuromyelitis optica spectrum disorder -- disease-modifying treatment -- DMT-associated infections -- progressive multifocal leukoencephalopathy -- coronavirus disease 2019 -- COVID-19 -- SARS-CoV-2 -- risk mitigation strategies; Central nervous system -- Diseases -- Periodicals; Myelin sheath -- Diseases -- Periodicals; Inflammation -- Periodicals; Multiple sclerosis -- Periodicals; Central Nervous System Diseases -- Periodicals; Demyelinating Diseases -- Periodicals; Inflammation -- Periodicals; Multiple Sclerosis -- Periodicals; Système nerveux central -- Maladies -- Périodiques; Gaine de myéline -- Maladies -- Périodiques; Inflammation (Pathologie) -- Périodiques; Sclérose en plaques -- Périodiques; Electronic journals; 616.834005
• DOI: 10.1177/13524585211069068
• Languages: English
• ISSNs: 1352-4585

Abstract

Over the recent years, the treatment of multiple sclerosis (MS) and neuromyelitis optica spectrum disorder (NMOSD) has evolved very rapidly and a large number of disease-modifying treatments (DMTs) are now available. However, most DMTs are associated with adverse events, the most frequent of which being infections. Consideration of all DMT-associated risks facilitates development of risk mitigation strategies. An international focused workshop with expert-led discussions was sponsored by the European Committee for Treatment and Research in Multiple Sclerosis (ECTRIMS) and was held in April 2021 to review our current knowledge about the risk of infections associated with the use of DMTs for people with MS and NMOSD and corresponding risk mitigation strategies. The workshop addressed DMT-associated infections in specific populations, such as children and pregnant women with MS, or people with MS who have other comorbidities or live in regions with an exceptionally high infection burden. Finally, we reviewed the topic of DMT-associated infectious risks in the context of the current SARS-CoV-2 pandemic. Herein, we summarize available evidence and identify gaps in knowledge which justify further research.