Versatile Polymer‐Initiating Biomineralization for Tumor Blockade Therapy (Adv. Mater. 19/2022). Issue 19 (12th May 2022)

• Record Type: Journal Article
• Authors: Jiang, Zhongyu; Liu, Yang; Shi, Run; Feng, Xiangru; Xu, Weiguo; Zhuang, Xiuli; Ding, Jianxun; Chen, Xuesi
• Is Part Of: Advanced materials. Volume 34:Issue 19(2022)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2022-05-12
• Subjects: biomineralization -- innovative cancer treatment -- multifunctional polymers -- osteoclast inhibition -- tumor blockade therapy; Materials -- Periodicals; Chemical vapor deposition -- Periodicals; 620.11
• DOI: 10.1002/adma.202270146
• Languages: English
• ISSNs: 0935-9648

Abstract

Abstract : Tumor Therapy In article number 2110094, Jianxun Ding and co‐workers develop a versatile polymer, 1, 2‐distearoyl‐ sn ‐glycero‐3‐phosphoethanolamine‐ N ‐poly(ethylene glycol)‐alendronate (DPA), for osteosarcoma blockade therapy. DPA not only initiates biomineralization in the peripheral tissue of tumors after insertion into the cytomembrane, but also alleviates bone destruction efficiently, both of which significantly inhibit the growth and lung metastasis of osteosarcoma.