Development and evaluation of a multi‐class analytical method based on solid‐phase extraction combined with liquid chromatography‐tandem mass spectrometry for the analysis of pharmaceuticals and personal care products in urban wastewater samples. Issue 5 (3rd March 2022)

• Record Type: Journal Article
• Authors: Konda, Satyanand; Asati, Ankita; Williams, Mike; Mudiam, Mohana Krishna Reddy
• Is Part Of: Separation science plus. Volume 5:Issue 5(2022)
• Page Start: 105
• Page End: 119
• Publication Date: 2022-03-03
• Subjects: Design of experiments -- liquid chromatography -- pharmaceuticals and personal care products -- tandem mass spectrometry -- Urban wastewater; Chromatographic analysis -- Periodicals; 543.8
• DOI: 10.1002/sscp.202100041
• Languages: English
• ISSNs: 2573-1815

Abstract

Abstract: An analytical method has been developed for the quantitative evaluation of 64 pharmaceuticals and personal care products in urban wastewater using solid‐phase extraction coupled with liquid chromatography‐tandem mass spectrometry. Design of experiments approach was used in the multiparametric optimization of solid‐phase extraction method for the analysis of pharmaceuticals and personal care products. The method was found to be linear within the range of 0.01–1 μg/L with coefficient of determination (R 2 ) ranging from 0.990 to 0.999. The limit of detection and limit of quantification were found to be in the range of 0.002–0.028 and 0.007–0.091 μg/L, respectively. The accuracy was calculated with respect to percent recovery, and it was found to be in the range of 70.0–129% for all the analytes. The intra‐ and interday precisions were found to be less than 15% relative standard deviation for all the analytes. The developed analytical method was applied to real samples collected from four different sampling sites of Musi River in Hyderabad to evaluate its performance. The method found a wide application for the analysis of urban wastewater samples.