All‐Optical Nanoscale Heating and Thermometry with Resonant Dielectric Nanoparticles for Controllable Drug Release in Living Cells. Issue 3 (6th February 2020)

• Record Type: Journal Article
• Authors: Zograf, George P.; Timin, Alexander S.; Muslimov, Albert R.; Shishkin, Ivan I.; Nominé, Alexandre; Ghanbaja, Jaafar; Ghosh, Pintu; Li, Qiang; Zyuzin, Mikhail V.; Makarov, Sergey V.
• Is Part Of: Laser & photonics reviews. Volume 14:Issue 3(2020)
• Page Start: n/a
• Page End: n/a
• Publication Date: 2020-02-06
• Subjects: dielectric nanophotonics -- drug delivery -- Mie‐resonances -- optical heating; Lasers -- Periodicals; Photonics -- Periodicals; Lasers -- Périodiques; Photonique -- Périodiques; 621.36
• DOI: 10.1002/lpor.201900082
• Languages: English
• ISSNs: 1863-8880

Abstract

Abstract: All‐dielectric nanophotonics becomes a versatile tool for various optical applications, including nanothermometry and optical heating. Its general concept includes excitation of Mie resonances in nonplasmonic nanoparticles. However, the potential of resonant dielectric nanoparticles in drug delivery applications still has not been fully realized. Here, optically resonant dielectric iron oxide nanoparticles (α‐Fe2 O3 NPs) are employed for remote rupture of microcontainers used as a drug delivery platform. It is theoretically and experimentally demonstrated that α‐Fe2 O3 NPs have several advantages in light‐to‐heat energy conversion comparing to previously used materials, such as noble metals and silicon, due to the broader spectral range of efficient optical heating, and in enhancement of thermally sensitive Raman signal. The α‐Fe2 O3 NPs embedded into the wall of universal drug carriers, polymer capsules, are used to experimentally determine the local temperature of the capsule rupture upon laser irradiation (170 °C). As a proof of principle, the delivery and remote release of anticancer drug vincristine upon lowered laser irradiation (4.0× 10 4 W cm −2 ) using polymer capsules modified with the α‐Fe2 O3 NPs is shown. The biological tests are performed on two primary cell types: i) carcinoma cells, as an example of malignant tumor, and ii) human stem cells, as a model of healthy cells. Abstract : The authors theoretically and experimentally demonstrate that optically resonant iron oxide nanoparticles (α‐Fe2 O3 NPs) have several advantages for light‐to‐heat energy conversion comparing to previously used materials, such as noble metals and silicon. The delivery and remote release of anticancer drug vincristine upon lowered laser irradiation using polymer capsules with the α‐Fe2 O3 NPs is shown.