Case–Control Study on Exercise-Induced Vasculitis in Hikers. (August 2022)

• Record Type: Journal Article
• Authors: Quéneau, Alexandre; Pistorius, Marc-Antoine; Connault, Jérôme; Raimbeau, Alizée; Gautier, Giovanni; Bergère, Guillaume; Artifoni, Mathieu; Durant, Cécile; Bénichou, Antoine; Hersant, Jeanne; Espitia, Olivier
• Is Part Of: Angiology. Volume 73:Number 7(2022)
• Page Start: 643
• Page End: 648
• Publication Date: 2022-08
• Subjects: exercise-induced vasculitis -- vasculitis -- hikers -- purpura; Blood-vessels -- Diseases -- Periodicals; Cardiovascular system -- Diseases -- Periodicals; 616.13005
• DOI: 10.1177/00033197211065792
• Languages: English
• ISSNs: 0003-3197

Abstract

The aim of this study was to identify clinical factors associated with exercise-induced vasculitis (EIV). This study included EIV cases and controls matched for age. Cases included were all members of a hiking club and participated in extended hiking trips. Exercise-induced vasculitis was diagnosed based on clinical signs occurring only after prolonged walks. Chronic venous disease was defined using the Clinical Etiological Anatomical Pathophysiologic classification. This study included 162 hikers: 32 EIV cases and 130 matched controls. Mean age at EIV diagnosis was 47.1 years and 24 (75.0%) of EIV cases were women. Chronic venous disease was present in 19 (57.6%) of EIV cases vs 39 (30.0%) in controls ( P = .001); those with EIV had significantly more saphenous vein insufficiency and C3 venous insufficiency than controls, 85.0 vs 52.6% and 8 (25.0%) vs 13 (10.0%) ( P = .02), respectively. For EIV cases, mean walking distance per hike was significantly higher than for controls ( P = .002). Exercise-induced vasculitis symptoms were typical with rash and/or purpura on the leg in warm conditions. Lesions spontaneously disappear in <10 days. In this study, EIV cases had more chronic venous disease and longer mean walking distances than controls.