Level I PD‐MCI Using Global Cognitive Tests and the Risk for Parkinson's Disease Dementia. Issue 4 (29th April 2022)

• Record Type: Journal Article
• Authors: Boel, Judith A.; de Bie, Rob M.A.; Schmand, Ben A.; Dalrymple‐Alford, John C.; Marras, Connie; Adler, Charles H.; Goldman, Jennifer G.; Tröster, Alexander I.; Burn, David J.; Litvan, Irene; Geurtsen, Gert J.
• Other Names: Bernard Bryan investigator.; Stebbins Glenn investigator.; Filoteo J. Vincent investigator.; Weintraub Daniel investigator.; Caviness John N. investigator.; Belden Christine investigator.; Zabetian Cyrus P. investigator.; Cholerton Brenna A. investigator.; Huang Xuemei investigator.; Eslinger Paul J. investigator.; Leverenz James B. investigator.; Duff‐Canning Sarah investigator.; Farrer Matt investigator.; Anderson Tim J. investigator.; Myall Daniel J. investigator.; Naismith Sharon L. investigator.; Lewis Simon J.G. investigator.; Halliday Glenda M. investigator.; Wu Ruey‐Meei investigator.; Williams‐Gray Caroline H. investigator.; Breen David P. investigator.; Barker Roger A. investigator.; Yarnall Alison J. investigator.; Klein Martin investigator.; Mollenhauer Brit investigator.; Trenkwalder Claudia investigator.; Kulisevsky Jaime investigator.; Pagonabarraga Javier investigator.; Gasca‐Salas Carmen investigator.; Rodriguez‐Oroz Maria C. investigator.; Junque Carme investigator.; Segura Barbara investigator.; Barone Paolo investigator.; Santangelo Gabriella investigator.; Cammisuli Davide M. investigator.; Biundo Roberta investigator.; Antonini Angelo investigator.; Weis Luca investigator.; Pedersen Kenn Freddy investigator.; Alves Guido investigator.;
• Is Part Of: Movement disorders clinical practice. Volume 9:Issue 4(2022)
• Page Start: 479
• Page End: 483
• Publication Date: 2022-04-29
• Subjects: dementia -- mild cognitive impairment -- global cognitive tests -- Parkinson's disease -- diagnostic accuracy; Movement Disorders; Movement disorders -- Periodicals; Movement disorders; Periodicals; Periodicals; 616
• DOI: 10.1002/mdc3.13451
• Languages: English
• ISSNs: 2330-1619

Abstract

ABSTRACT: Background: The criteria for PD‐MCI allow the use of global cognitive tests. Their predictive value for conversion from PD‐MCI to PDD, especially compared to comprehensive neuropsychological assessment, is unknown. Methods: The MDS PD‐MCI Study Group combined four datasets containing global cognitive tests as well as a comprehensive neuropsychological assessment to define PD‐MCI (n = 467). Risk for developing PDD was examined using a Cox model. Global cognitive tests were compared to neuropsychological test batteries (Level I&II) in determining risk for PDD. Results: PD‐MCI based on a global cognitive test (MMSE or MoCA) increases the hazard for developing PDD (respectively HR = 2.57, P = 0.001; HR = 4.14, P = <0.001). The C‐statistics for MMSE (0.72) and MoCA (0.70) were lower than those based on neuropsychological tests (Level I = 0.82; Level II = 0.81). Sensitivity, specificity and diagnostic accuracy balance was best in Level II. Conclusion: MMSE and MoCA predict conversion to PDD. However, Level II neuropsychological assessment seems the preferred assessment for PD‐MCI.