Blunted rest-activity rhythm is associated with increased white blood-cell-based inflammatory markers in adults: an analysis from NHANES 2011-2014. (3rd June 2022)

• Record Type: Journal Article
• Authors: Xu, Yanyan; Su, Shaoyong; McCall, William V.; Wang, Xiaoling
• Is Part Of: Chronobiology international. Volume 39:Number 6(2022)
• Page Start: 895
• Page End: 902
• Publication Date: 2022-06-03
• Subjects: Rest-activity rhythm -- circadian rhythm -- WBC count -- inflammation; Chronobiology -- Periodicals; Biological rhythms -- Periodicals; Circadian rhythms -- Periodicals; 571.77
• DOI: 10.1080/07420528.2022.2048663
• Languages: English
• ISSNs: 0742-0528

Abstract

ABSTRACT: Circadian rhythm disruption is associated with immune system disturbance and has been observed in many health problems where chronic-inflammation acts as a major contributor. We aim to examine whether rest-activity circadian rhythm is associated with chronic inflammation using white blood-cell-based inflammatory indices including white blood cell (WBC) count, neutrophil count, neutrophil-to-lymphocyte ratio (NLR) and systemic immune-inflammation index (SII). We analyzed the data from 8089 adults (age≥20) with at least 4 days of validated accelerometer recordings and a valid WBC count from the National Health and Nutrition Examination Survey (NHANES) 2011–2014. Non-parametric rest-activity circadian rhythm parameters were derived from the accelerometer recordings. In the models adjusting multiple covariates, a one-quantile increase in relative amplitude (i.e. more robust circadian rhythm) was associated with 1 × 10 8 cells/L decrease in WBC number (95% CI: 5 × 10 7 to 1.5 × 10 8, P < .001), 7 × 10 7 cells/L decrease in neutrophils (95% CI: 3 × 10 7 to 1.1 × 10 8, P = .003) and 15.2 × 10 9 /L decrease in SII (95% CI: 6 × 10 9 /L to 20 × 10 9 /L, P = .019). Consistent results were also observed for the association of M10 value and L5 value with these inflammatory indices. Our results indicated that blunted rest-activity circadian rhythm is associated with increased white blood-cell-based inflammatory indices in adults, suggesting interventions aiming at enhancing circadian rhythm by lifestyle programs may be a novel approach to improve the general health.