Development of Biodegradable Delivery Systems Containing Novel 1, 2, 4-Trioxolane Based on Bacterial Polyhydroxyalkanoates. (28th February 2022)

• Record Type: Journal Article
• Authors: Lipaikin, Sergei Y.; Yaremenko, Ivan A.; Terent'ev, Alexander O.; Volova, Tatiana G.; Shishatskaya, Ekaterina I.
• Other Names: Gualandi Chiara Academic Editor.
• Is Part Of: Advances in polymer technology. Volume 2022(2022)
• Publication Date: 2022-02-28
• Subjects: Plastics -- Periodicals; Polymers -- Periodicals; 668.9
• DOI: 10.1155/2022/6353909
• Languages: English
• ISSNs: 0730-6679

Abstract

Abstract : In this work, delivery systems in the form of microparticles and films containing 1, 2, 4-trioxolane (ozonide, OZ) based on polyhydroxyalkanoates (PHAs) were developed. Main systems' characteristics were investigated: the particle yield, average diameter, zeta potential, surface morphology, loading capacity, and drug release profile of microparticles, as well as surface morphology and release profiles of OZ-containing films. PHA-based OZ-loaded microparticles have been found to have satisfactory size, zeta potential, and ozonide loading-release behavior. It was noted that OZ content influenced the surface morphology of obtained systems.