Impaired memory by hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic fields is ameliorated by thymoquinone. Issue 1 (2nd January 2022)

• Record Type: Journal Article
• Authors: Ustunova, Savas; Kilic, Aysu; Bulut, Huri; Gurel-Gurevin, Ebru; Eris, Ali Hikmet; Meral, Ismail
• Is Part Of: Toxicological and environmental chemistry. Volume 104:Issue 1(2022)
• Page Start: 176
• Page End: 193
• Publication Date: 2022-01-02
• Subjects: 900 MHz EMF -- cognitive functions -- hippocampus -- oxidative stress -- thymoquinone; Toxicology -- Periodicals; Environmental chemistry -- Periodicals; 571.95
• DOI: 10.1080/02772248.2022.2051509
• Languages: English
• ISSNs: 0277-2248

Abstract

Abstract: The protective effects of thymoquinone on learning and memory abilities and on hippocampal oxidative stress in rats exposed to 900 MHz electromagnetic field radiation at s strength of 6.0 ± 0.5 V/m for 1 h on each of 15 days was studied. Thymoquinone-treatment (10 mg/kg/day) of radiation-exposed rats resulted in better performance than that of radiation-exposed rats not receiving thymoquinone. Electromagnetic field-exposure led to increased hippocampal superoxide dismutase, glutathione peroxidase, and malondialdehyde levels and to lowered brain-derived neurotrophic factor level; thymoquinone treatment ameliorated all four parameters. Also, in the electromagnetic field-exposed group, N -methyl-D-aspartate receptor expression decreased, and gamma-aminobutyric-acid alpha receptor expression increased, which was reversed by thymoquinone treatment. In conclusion, treatment with the thymoquinone ameliorated the impact of the exposure to EMF and provided a hint on the mechanism involving oxidative stress.