A new pair of cytotoxic enantiomeric isoprenylated chromone derivatives from Pestalotiopsis sp. Issue 6 (3rd June 2022)

• Record Type: Journal Article
• Authors: Yang, Bei-Ye; Sun, Wei-Guang; Liu, Jun-Jun; Wang, Jian-Ping; Hu, Zheng-Xi; Zhang, Yong-Hui
• Is Part Of: Journal of Asian natural products research. Volume 24:Issue 6(2022)
• Page Start: 528
• Page End: 534
• Publication Date: 2022-06-03
• Subjects: Fungus -- Pestalotiopsis sp. -- enantiomers -- ECD calculation -- cytotoxicity; Materia medica -- Asia -- Periodicals; Pharmacognosy -- Asia -- Periodicals; Medicinal plants -- Asia -- Periodicals; Medicine, Oriental -- Asia -- Periodicals; 615.321095
• DOI: 10.1080/10286020.2021.1946042
• Languages: English
• ISSNs: 1028-6020

Abstract

Abstract: A new pair of enantiomeric isoprenylated chromone derivatives, (±)-pestaloficiol X [(±)-1 ], along with a known compound pestaloficiol J (2 ), were isolated from the plant endophytic fungus Pestalotiopsis sp. The racemic mixture 1 was separated through chiral HPLC. The structures of new compounds (±)-1 were elucidated on the basis of extensive spectroscopic data and their absolute configurations were further configured through computational analysis of their electronic circular dichroism (ECD) spectra. Compound (+)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC50 values of 1.35 ± 0.15 and 3.70 ± 0.33 μM, respectively, while compound (–)-1 showed significant inhibitory potency against HL-60 and HEP-3B cell lines, with IC50 values of 2.39 ± 0.26 and 2.99 ± 0.35 μM, respectively. Abstract : UF0001