Early brain activity: Translations between bedside and laboratory. (June 2022)

• Record Type: Journal Article
• Authors: Luhmann, Heiko J.; Kanold, Patrick O.; Molnár, Zoltán; Vanhatalo, Sampsa
• Is Part Of: Progress in neurobiology. Volume 213(2022)
• Publication Date: 2022-06
• Subjects: CR Cajal-Retzius (neuron) -- ECoG electrocorticogram -- EMG electromyography -- FbEEG Full-band EEG -- fMRI functional magnetic resonance imaging -- fUS functional ultrasound imaging -- IVH intraventricular hemorrhage -- IOS Intrinsic optical signal -- L (cortical) layer -- MEA multi-electrode array -- MEG magnetoencephalography -- NICU neonatal intensive care unit -- NIRS near infrared spectroscopy -- NVC neurovascular coupling -- SATs spontaneous activity transients -- VSDI voltage-sensitive dye imaging; Biomarker -- Development -- Animal model -- Human -- Neuronal activity -- Cerebral cortex; Neurobiology -- Periodicals; Neurology -- Periodicals; Neurology -- Periodicals; Neurobiologie -- Périodiques; 612.8
• DOI: 10.1016/j.pneurobio.2022.102268
• Languages: English
• ISSNs: 0301-0082

Abstract

Abstract: Neural activity is both a driver of brain development and a readout of developmental processes. Changes in neuronal activity are therefore both the cause and consequence of neurodevelopmental compromises. Here, we review the assessment of neuronal activities in both preclinical models and clinical situations. We focus on issues that require urgent translational research, the challenges and bottlenecks preventing translation of biomedical research into new clinical diagnostics or treatments, and possibilities to overcome these barriers. The key questions are (i) what can be measured in clinical settings versus animal experiments, (ii) how do measurements relate to particular stages of development, and (iii) how can we balance practical and ethical realities with methodological compromises in measurements and treatments. Graphical Abstract: ga1 Highlights: Early activity is both the cause and the consequence of developmental abnormalities. Network brain activity can be used as a readout of developmental abnormality. Transient cortical neurons and circuits shape cortical development. Translational challenges in understanding and diagnosing developmental brain disorders. We review (i) what (ii) how and (iii) why the early activity should be measured.