The influence of metabolic imbalances and oxidative stress on the outcome of critically ill polytrauma patients: a review. Issue 1 (7th March 2017)

• Record Type: Journal Article
• Authors: Rogobete, Alexandru Florin; Sandesc, Dorel; Papurica, Marius; Stoicescu, Emil Robert; Popovici, Sonia Elena; Bratu, Lavinia Melania; Vernic, Corina; Sas, Adriana Mariana; Stan, Adrian Tudor; Bedreag, Ovidiu Horea
• Is Part Of: Burns and trauma. Volume 5:Issue 1(2017)
• Publication Date: 2017-03-07
• Subjects: Critically ill -- Energy expenditure -- Indirect calorimetry -- Metabolic disaster -- Oxidative stress -- Overfeeding -- Underfeeding -- Polytrauma; Burns and scalds -- Periodicals; Wounds and injuries -- Periodicals; 617.11
• DOI: 10.1186/s41038-017-0073-0
• Languages: English
• ISSNs: 2321-3876

Abstract

Abstract: The critically ill polytrauma patient presents with a series of associated pathophysiologies secondary to the traumatic injuries. The most important include systemic inflammatory response syndrome (SIRS), sepsis, oxidative stress (OS), metabolic disorders, and finally multiple organ dysfunction syndrome (MODS) and death. The poor outcome of these patients is related to the association of the aforementioned pathologies. The nutrition of the critically ill polytrauma patient is a distinct challenge because of the rapid changes in terms of energetic needs associated with hypermetabolism, sepsis, SIRS, and OS. Moreover, it has been proven that inadequate nutrition can prolong the time spent on a mechanical ventilator and the length of stay in an intensive care unit (ICU). A series of mathematical equations can predict the energy expenditure (EE), but they have disadvantages, such as the fact that they cannot predict the EE accurately in the case of patients with hypermetabolism. Indirect calorimetry (IC) is another method used for evaluating and monitoring the energy status of critically ill patients. In this update paper, we present a series of pathophysiological aspects associated with the metabolic disaster affecting the critically ill polytrauma patient. Furthermore, we present different non-invasive monitoring methods that could help the intensive care physician in the adequate management of this type of patient.