Decay of HIV DNA in the Reservoir and the Impact of Short Treatment Interruption in Kenyan Infants. (9th December 2017)

• Record Type: Journal Article
• Authors: Pankau, Mark D; Wamalwa, Dalton; Benki-Nugent, Sarah; Tapia, Kenneth; Ngugi, Evelyn; Langat, Agnes; Otieno, Vincent; Moraa, Helen; Maleche-Obimbo, Elizabeth; Overbaugh, Julie; John-Stewart, Grace C; Lehman, Dara A
• Is Part Of: Open forum infectious diseases. Volume 5:Number 1(2018)
• Publication Date: 2017-12-09
• Subjects: antiretroviral therapy -- HIV DNA -- infants -- reservoir -- treatment interruption; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofx268
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: We compared change in HIV reservoir DNA following continued antiretroviral therapy (ART) vs short treatment interruption (TI) in early ART-treated Kenyan infants. While HIV DNA in the reservoir decayed with continued ART, HIV DNA levels were similar to pre-TI HIV DNA reservoir levels in most children after short TI.