Polymorphism in STAT4 Increase the Risk of Systemic Lupus Erythematosus: An Updated Meta-Analysis. (22nd April 2022)

• Record Type: Journal Article
• Authors: Shancui-zheng, ; Jinping-Zhang, ; Guoyuan-lu, ; Liu, Lei; Zhiyong-deng,
• Other Names: Dessein Patrick H. Academic Editor.
• Is Part Of: International journal of rheumatology. Volume 2022(2022)
• Publication Date: 2022-04-22
• Subjects: Rheumatology -- Periodicals; Rheumatology; Rheumatology; Electronic journals; Periodicals; Periodicals; 616.723
• DOI: 10.1155/2022/5565057
• Languages: English
• ISSNs: 1687-9260

Abstract

Abstract : Previous studies have reported that STAT4 rs7574865 conferred the susceptibility to systemic lupus erythematosus (SLE). In this study, a meta-analysis (including 32 comparative studies of 11384 patients and 17609 controls) was conducted to investigate the role of STAT4 polymorphism in SLE in a comprehensive way. We found that the Asian population had the highest prevalence of the T allele than any other study population at 32.2% and that STAT4 rs7574865 polymorphism was associated with SLE in the overall population (OR = 1.579, 95 % CI = 1.497 -1.665, P < 0.001 ). In the subgroup analysis by ethnicity, STAT4 rs7574865 T allele was shown to be risk factor in SLE in Asian, European, and American origins. Our results do support STAT4 rs7574865 polymorphism as a susceptibility factor for SLE in populations of different ethnic and that its prevalence is ethnicity dependent.