Stimulus-activatable echogenic maltodextrin nanoparticles as nanotheranostic agents for peripheral arterial disease. (February 2019)

• Record Type: Journal Article
• Authors: Jung, Eunkyeong; Lee, Jeonghun; Jeong, Lipjeong; Park, Sanghun; Lee, Moungyoung; Song, Chulgyu; Lee, Dongwon
• Is Part Of: Biomaterials. Volume 192(2019)
• Page Start: 282
• Page End: 291
• Publication Date: 2019-02
• Subjects: Reactive oxygen species -- Peripheral arterial diseases -- Ultrasound imaging -- Photoacoustic imaging -- Fluorescence imaging -- Angiogenesis; Biomedical materials -- Periodicals; Biocompatible Materials -- Periodicals; Biomatériaux -- Périodiques; 610.28
• DOI: 10.1016/j.biomaterials.2018.11.022
• Languages: English
• ISSNs: 0142-9612

Abstract

Abstract: Reactive oxygen species (ROS) are closely related with various pathological disorders. Therefore, real-time detection of ROS is essential for understanding the procedure of diseases and diagnosing the accurate lesion sites. Hydrogen peroxide (H2 O2 ) accounts for a large portion of ROS and has a longer half-life than other ROS, which makes it a highly promising diagnostic and therapeutic biomarker. In this work, we developed H2 O2 -activatable CO2 bubble generating indocyanine green-loaded boronated maltodextrin (ICG-BM) nanoparticles for imaging and therapy of peripheral arterial disease. ICG-BM nanoparticles displayed increasing fluorescence, ultrasound and photoacoustic signals in H2 O2 -triggered manners and exerted significant anti-inflammatory and proangiogenic effects in H2 O2 -stimulated vascular endothelial cells. In mouse models of hindlimb ischemia, ICG-BM nanoparticles also showed H2 O2 -triggered amplification of fluorescence, ultrasound and photoacoustic signals in the ischemic hindlimb muscles. ICG-BM nanoparticles also significantly reduced the level of overproduced H2 O2 and exerted highly potent anti-inflammatory and proangiogenic activities in the ischemic tissues. We therefore believe that pathological stimulus-activatable echogenic ICG-BM nanoparticles provide a new avenue for imaging and treatment of peripheral arterial disease. Graphical abstract: Image 1