Staphylococcus aureus nasal colonization increases the risk of cedar pollinosis. (1st March 2022)

• Record Type: Journal Article
• Authors: Morizane, Atsushi; Uehara, Yoshio; Kitamura, Satoko; Komori, Masahiro; Matsushita, Masahide; Takeuchi, Seisho; Seo, Hiromi
• Is Part Of: Journal of general and family medicine. Volume 23:Number 3(2022)
• Page Start: 172
• Page End: 176
• Publication Date: 2022-03-01
• Subjects: cedar pollinosis -- clonal complex -- MLST -- Staphylococcus aureus; Primary care (Medicine) -- Periodicals; Family medicine -- Periodicals; Family Practice; Primary Health Care; Japan; Periodicals; 610
• DOI: 10.1002/jgf2.530
• Languages: English
• ISSNs: 2189-7948

Abstract

Abstract: Background: One‐third of the people in Japan are colonized with Staphylococcus aureus ( S . aureus ) and suffer from virulence factor‐mediated subclinical inflammation of the nares. We investigated whether subclinical inflammation contributed to cedar pollinosis affecting 20 million people annually. Methods: The study participants were 814 inhabitants of the A or B prefectures. We compared the colonization rate and population structure of S . aureus, in association with the prevalence of cedar pollinosis, between participants in these two areas. Results: A prefecture had twice the annual amount of airborne cedar pollen compared with B. The prevalence of cedar pollinosis was significantly higher in A (23.5%) than in B (13.1%) ( p = 0.0004). Moreover, the prevalence of cedar pollinosis was higher in female participants (23.3%) than in male participants (14.7%) ( p = 0.003). In addition, the prevalence of cedar pollinosis was higher in S. aureus carriers (24.2%) than in S. aureus noncarriers (17.9%) ( p = 0.03). The isolation rate of clonal complex (CC) 508 was higher in the A group (21%) than in the B group (7%) ( p = 0.015). Conclusion: Nasal colonization of S . aureus is a major risk factor for cedar pollinosis. However, the direct mechanism of this risk is currently unknown. Abstract : The prevalence of cedar pollinosis in the research area was proportional to the amount of cedar pollen. The prevalence of cedar pollinosis was higher in S. aureus carriers (24.2%) than in S. aureus noncarriers (17.9%) ( p = 0.03). The prevalence of cedar pollinosis was higher in female participants (23.3%) than in male participants (14.7%) ( p = 0.003).