Self-assembling GO/modified HEC hybrid stabilized pickering emulsions and template polymerization for biomedical hydrogels. (1st March 2019)

• Record Type: Journal Article
• Authors: Wang, Xiangdong; Yu, Kexin; An, Ran; Han, Linglin; Zhang, Yulin; Shi, Lingying; Ran, Rong
• Is Part Of: Carbohydrate polymers. Volume 207(2019)
• Page Start: 694
• Page End: 703
• Publication Date: 2019-03-01
• Subjects: Graphene oxide -- HEC -- Pickering emulsion -- Hydrogel -- Biomedical material; Polysaccharides -- Periodicals; Polysaccharides -- Periodicals; Polysaccharides -- Périodiques; Electronic journals; 547.78
• DOI: 10.1016/j.carbpol.2018.12.034
• Languages: English
• ISSNs: 0144-8617

Abstract

Highlights: The hydrophobic modified HEC which contained quaternary ammonium group. GO which the water contact angle was 84°–86°. Pickering emulsion was fabricated by a low concentration of GO and modified HEC. The biomedical PAM hydrogel by emulsion template for drug controlled-release. Pickering particles, polymer and the monomer of hydrogel can all be varied. Abstract: Graphene oxide(GO), as an amphiphilic and biocompatible material, is often used to prepare Pickering emulsion. However, the preparation of stable Pickering emulsion by a low concentration of GO is very challenging. In this research, we prepared the hydrophobic modified hydroxyethyl cellulose (mHEC) which contained quaternary ammonium group and GO which the water contact angle was 84°–86°. A stable, low cost, and biocompatible Pickering emulsion was fabricated by a low concentration of GO and different contents of mHEC. The effects of mHEC concentration, electrolyte concentration, pH, and oil/water ratio on the stability of Pickering emulsion were investigated. What's more, we prepared the biomedical macroporous polyacrylamide hydrogel by the GO/mHEC composite stabilized emulsion template for drug controlled-release. The composite hydrogel by Pickering emulsion template is a potential drug controlled-release delivery platforms. Furthermore, our strategy is extremely versatile, as Pickering particles, polymer and the monomer of hydrogel can all be varied.