Homo‐ and Heteroleptic Phototoxic Dinuclear Metallo‐Intercalators Based on RuII(dppn) Intercalating Moieties: Synthesis, Optical, and Biological Studies. (7th September 2017)

• Record Type: Journal Article
• Authors: Saeed, Hiwa K.; Jarman, Paul J.; Archer, Stuart; Sreedharan, Sreejesh; Saeed, Ibrahim Q.; Mckenzie, Luke K.; Weinstein, Julia A.; Buurma, Niklaas J.; Smythe, Carl G. W.; Thomas, Jim A.
• Is Part Of: Angewandte Chemie. Volume 129:Number 41(2017)
• Page Start: 12802
• Page End: 12807
• Publication Date: 2017-09-07
• Subjects: Lumineszenz -- Metallointerkalatoren -- Photodynamische Therapie -- Ruthenium(II) -- Singulett-Sauerstoff; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.201707350
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Using a new mononuclear "building block, " for the first time, a dinuclear Ru II (dppn) complex and a heteroleptic system containing both Ru II (dppz) and Ru II (dppn) moieties are reported. The complexes, including the mixed dppz/dppn system, are 1 O2 sensitizers. However, unlike the homoleptic dppn systems, the mixed dppz/dppn complex also displays a luminescence "switch on" DNA light‐switch effect. In both cisplatin sensitive and resistant human ovarian carcinoma lines the dinuclear complexes show enhanced uptake compared to their mononuclear analogue. Thanks to a favorable combination of singlet oxygen generation and cellular uptake properties all three of the new complexes are phototoxic and display potent activity against chemotherapeutically resistant cells. Abstract : 2 für die PDT : Neue zweikernige Ru II (dppn)‐ und gemischte Ru II (dppn)/Ru II (dppz)‐Komplexe werden deutlich besser in Zellen aufgenommen als die einfachen Ru II (dppz)‐Analoga. Sie sind phototoxisch und wirken insbesondere gegen Chemotherapeutika‐resistente Zellen. Der lumineszierende Ru II (dppn)/Ru II (dppz)‐Komplex hat außerdem Potenzial als theranostische Leitstruktur.