Gold‐Triggered Uncaging Chemistry in Living Systems. Issue 41 (9th August 2017)

• Record Type: Journal Article
• Authors: Pérez‐López, Ana M.; Rubio‐Ruiz, Belén; Sebastián, Víctor; Hamilton, Lloyd; Adam, Catherine; Bray, Thomas L.; Irusta, Silvia; Brennan, Paul M.; Lloyd‐Jones, Guy C.; Sieger, Dirk; Santamaría, Jesús; Unciti‐Broceta, Asier
• Is Part Of: Angewandte Chemie international edition. Volume 56:Issue 41(2017)
• Page Start: 12548
• Page End: 12552
• Publication Date: 2017-08-09
• Subjects: bioorthogonal -- fluorescent probes -- gold -- heterogeneous catalysis -- prodrugs; Chemistry -- Periodicals; 540
• DOI: 10.1002/anie.201705609
• Languages: English
• ISSNs: 1433-7851

Abstract

Abstract: Recent advances in bioorthogonal catalysis are increasing the capacity of researchers to manipulate the fate of molecules in complex biological systems. A bioorthogonal uncaging strategy is presented, which is triggered by heterogeneous gold catalysis and facilitates the activation of a structurally diverse range of therapeutics in cancer cell culture. Furthermore, this solid‐supported catalytic system enabled locally controlled release of a fluorescent dye into the brain of a zebrafish for the first time, offering a novel way to modulate the activity of bioorthogonal reagents in the most fragile and complex organs. Abstract : Hidden in the glorious wildness like unmined gold ! A bioorthogonal uncaging strategy triggered by heterogeneous gold catalysis mediates the activation of probes and therapeutics both in vitro and in vivo. Scale bar: 100 μm.