Disrupted topological organization of resting‐state functional brain networks in cerebral small vessel disease. Issue 8 (15th February 2022)

• Record Type: Journal Article
• Authors: Xin, Haotian; Wen, Hongwei; Feng, Mengmeng; Gao, Yian; Sui, Chaofan; Zhang, Nan; Liang, Changhu; Guo, Lingfei
• Is Part Of: Human brain mapping. Volume 43:Issue 8(2022)
• Page Start: 2607
• Page End: 2620
• Publication Date: 2022-02-15
• Subjects: cerebral microbleeds -- cerebral small vessel disease -- functional connectivity -- graph theory -- topological organization; Brain mapping -- Periodicals; 611.81
• DOI: 10.1002/hbm.25808
• Languages: English
• ISSNs: 1065-9471

Abstract

Abstract: We aimed to investigate alterations in functional brain networks and assess the relationship between functional impairment and topological network changes in cerebral small vessel disease (CSVD) patients with and without cerebral microbleeds (CMBs). We constructed individual whole‐brain, region of interest (ROI) level functional connectivity (FC) networks for 24 CSVD patients with CMBs (CSVD‐c), 42 CSVD patients without CMBs (CSVD‐n), and 36 healthy controls (HCs). Then, we used graph theory analysis to investigate the global and nodal topological disruptions between groups and relate network topological alterations to clinical parameters. We found that both the CSVD and control groups showed efficient small‐world organization in FC networks. However, compared to CSVD‐n patients and controls, CSVD‐c patients exhibited a significantly decreased clustering coefficient, global efficiency, and local efficiency and an increased shortest path length, indicating a disrupted balance between local specialization and global integration in FC networks. Although both the CSVD and control groups showed highly similar hub distributions, the CSVD‐c group exhibited significantly altered nodal betweenness centrality (BC), mainly distributed in the default mode network (DMN), attention, and visual functional areas. There were almost no global or regional alterations between CSVD‐n patients and controls. Furthermore, the altered nodal BC of the right anterior/posterior cingulate gyrus and left cuneus were significantly correlated with cognitive parameters in CSVD patients. These results suggest that CSVD patients with and without CMBs had segregated disruptions in the topological organization of the intrinsic functional brain network. This study advances our current understanding of the pathophysiological mechanisms underlying CSVD. Abstract : We used whole‐brain ROI‐level FC analysis and graph theory analysis to investigate the altered topological organization of FC networks in CSVD. These results suggest that CSVD patients with and without CMBs had segregated disruptions in the topological organization of the intrinsic functional brain network, which may be due to different etiological contributions. These findings may extend our understanding of how functional disruptions of neuronal circuits are linked to the pathophysiology of CSVD.