Identifying Missing Biosynthesis Enzymes of Plant Natural Products. (March 2020)

• Record Type: Journal Article
• Authors: Dugé de Bernonville, Thomas; Papon, Nicolas; Clastre, Marc; O'Connor, Sarah E.; Courdavault, Vincent
• Is Part Of: Trends in pharmacological sciences. Volume 41:Number 3(2020)
• Page Start: 142
• Page End: 146
• Publication Date: 2020-03
• Subjects: specialized metabolites -- gene identification -- RNA-seq -- whole genome sequencing -- coexpression network; Pharmacology -- Periodicals; Pharmacology -- trends -- Periodicals; Pharmacologie -- Périodiques; Pharmacology; Electronic journals; Periodicals; 615.1
• DOI: 10.1016/j.tips.2019.12.006
• Languages: English
• ISSNs: 0165-6147

Abstract

Abstract : Elucidating plant-specialized biosynthetic pathways has always constituted a laborious task, notably for natural products with high pharmaceutical values. Here, we discuss emerging omics-based strategies that facilitate the identification of genes from these complex metabolic pathways, paving the way to engineered supplies of these compounds through synthetic biology approaches.