Fluorination Enhances NIR‐II Fluorescence of Polymer Dots for Quantitative Brain Tumor Imaging. (8th September 2020)

• Record Type: Journal Article
• Authors: Liu, Ye; Liu, Jinfeng; Chen, Dandan; Wang, Xiaosha; Zhang, Zhe; Yang, Yicheng; Jiang, Lihui; Qi, Weizhi; Ye, Ziyuan; He, Shuqing; Liu, Quanying; Xi, Lei; Zou, Yingping; Wu, Changfeng
• Is Part Of: Angewandte Chemie. Volume 132:Number 47(2020)
• Page Start: 21235
• Page End: 21243
• Publication Date: 2020-09-08
• Subjects: brain tumors -- fluorescent probes -- fluorination -- NIR-II optical imaging -- polymer dots; Chemistry -- Periodicals; 540
• DOI: 10.1002/ange.202007886
• Languages: English
• ISSNs: 0044-8249

Abstract

Abstract: Here, we describe a fluorination strategy for semiconducting polymers for the development of highly bright second near‐infrared region (NIR‐II) probes. Tetrafluorination yielded a fluorescence QY of 3.2 % for the polymer dots (Pdots), over a 3‐fold enhancement compared to non‐fluorinated counterparts. The fluorescence enhancement was attributable to a nanoscale fluorous effect in the Pdots that maintained the molecular planarity and minimized the structure distortion between the excited state and ground state, thus reducing the nonradiative relaxations. By performing through‐skull and through‐scalp imaging of the brain vasculature of live mice, we quantitatively analyzed the vascular morphology of transgenic brain tumors in terms of the vessel lengths, vessel branches, and vessel symmetry, which showed statistically significant differences from the wild type animals. The bright NIR‐II Pdots obtained through fluorination chemistry provide insightful information for precise diagnosis of the malignancy of the brain tumor. Abstract : Fluorination of semiconducting polymers resulted in highly bright polymer dots (QY=3.2 %) in the NIR‐II region. By performing through‐skull and through‐scalp imaging of the mouse brain, the vascular morphology of transgenic brain tumors was quantitatively analyzed.