Addendum zu Chlorbenzol [BAT value documentation in German language, 2019]. Issue 3 (25th July 2019)

• Record Type: Journal Article
• Authors: Nasterlack, M.; Drexler, H.; Hartwig, A.
• Is Part Of: MAK collection for occupational health and safety. Volume 4:Issue 3(2019)
• Page Start: 1645
• Page End: 1650
• Publication Date: 2019-07-25
• Subjects: Chlorbenzol -- Monochlorbenzol -- Benzolchlorid -- Phenylchlorid -- Arbeitsstoff -- biologischer Toleranzwert -- BAT‐Wert -- biologischer Leitwert -- Toxizität; Biological monitoring -- Periodicals; Industrial toxicology -- Periodicals; Hazardous substances -- Periodicals; 615.902
• DOI: 10.1002/3527600418.bb10890d0024
• Languages: English
• ISSNs: 2509-2383

Abstract

Abstract: In 2018, the German Commission for the Investigation of Health Hazards of Chemical Compounds in the Work Area has re‐evaluated chlorobenzene after the MAK value for this substance had been lowered from 10 to 5 mL/m 3 . Therefore, the BAT value has to be re‐evaluated. Urinary excretion of 4‐chlorocatechol, the main metabolite of chlorobenzene, is considered to be the most appropriate biomarker after inhalation exposure. Available publications are described in detail. The regression equations derived from these studies agree well with each other. After an 8‐hour exposure to chlorobenzene a mean urinary excretion of 80 mg 4‐chlorocatechol per g creatinine can be expected. This value is set as BAT value. Sampling time is at the end of exposure or end of shift.