Association between omega-3 fatty acid supplementation and lower risk of preterm delivery: a systematic review and meta-analysis. (18th June 2022)

• Record Type: Journal Article
• Authors: Sun, Lu; Li, Yuxin; Xie, Wei; Xue, Xiaoou
• Is Part Of: Journal of maternal-fetal & neonatal medicine. Volume 35:Number 12(2022)
• Page Start: 2294
• Page End: 2303
• Publication Date: 2022-06-18
• Subjects: Omega-3 fatty acid -- preterm delivery -- meta-analysis -- RCTs -- gestational age; Obstetrics -- Periodicals; Perinatology -- Periodicals; Infants (Newborn) -- Diseases -- Periodicals; Neonatology -- Periodicals; 618.2
• DOI: 10.1080/14767058.2020.1785423
• Languages: English
• ISSNs: 1476-7058

Abstract

Abstract: Objective: To explore whether omega-3 fatty acid supplementation is associated with lower risk of preterm delivery. Methods: Searching the RCTs which were compared preterm birth between women with omega-3 fatty acid supplementation and without before December 2019 on Medline, EMBASE and Cochrane's Library, then performing a meta-analysis. Results: 26 trials were identified, included 20124 women. There was almost no association between omega-3 fatty acid supplementation and lower risk of preterm delivery (risk ratio 0.92, 95% confidence interval 0.85 to 1.01, I 2 = 9%), gestational duration (0.30, −0.05 to 0.64, I 2 = 48%). In subgroup analyses, preterm delivery lower rate occurred in groups with mixed DHA and EPA supplementation not only DHA supplementation groups (P for interaction = 0.02); The dose of equivalent greater than 1 g made a higher reduction in preterm birth significantly. Conclusions: Omega-3 fatty acid supplementation was not associated with reduced risk of preterm delivery compared with placebo or no treatment during pregnancy. Relationship between Omega-3 fatty acid supplementation and other pregnant outcomes need more evidence and clinical studies.