A Glucagonoma Presenting as Cerebral Vein Thrombosis and Diabetes. (22nd April 2022)

• Record Type: Journal Article
• Authors: Delli Colli, Marina; Alamri, Bader N.; Palma, Laura; Rivera, Juan
• Other Names: Kita Toshihiro Academic Editor.
• Is Part Of: Case reports in endocrinology. Volume 2022(2022)
• Publication Date: 2022-04-22
• Subjects: Endocrinology -- Periodicals; Endocrinology -- Case studies -- Periodicals; Endocrine glands -- Diseases -- Periodicals; Endocrinology; Endocrine System Diseases; Endocrine glands -- Diseases; Endocrinology; Electronic journals; Periodicals; Case studies; Periodicals; Case Reports; Fulltext; Internet Resources; Periodicals; 616.4
• DOI: 10.1155/2022/7659341
• Languages: English
• ISSNs: 2090-6501

Abstract

Abstract : Glucagonomas are rare pancreatic neuroendocrine tumors (pNETs), malignant in 80% of cases, thus highlighting the importance of early diagnosis and treatment. Primary manifestations are diabetes, dermatosis, depression, weight loss, and deep vein thrombosis. Unlike other pNETs, glucagonomas are associated with a higher incidence of thromboembolic events, often resulting in death. We present the case of a glucagonoma patient whose primary manifestation was cerebral sinus venous thrombosis (CS-VT). Early diagnosis enabled curative resection. The purpose of this paper is to review the underlying mechanisms associated with increased coagulopathy in glucagonomas.