A Mixed-Effects Model of Associations Between Interleukin-6 and Hippocampal Volume. Issue 4 (12th October 2021)

• Record Type: Journal Article
• Authors: Harrell, Erin R; Bui, Chuong; Newman, Sharlene D
• Editors: Le Couteur, David G
• Is Part Of: Journals of gerontology. Volume 77:Issue 4(2022)
• Page Start: 683
• Page End: 688
• Publication Date: 2021-10-12
• Subjects: Cognitive decline -- Inflammation -- Memory -- Stress-related cytokines; Geriatrics -- Periodicals; Gerontology -- Periodicals; 618.97
• DOI: 10.1093/gerona/glab313
• Languages: English
• ISSNs: 1079-5006

Abstract

Abstract: Previous studies report hippocampal volume loss can help predict conversion from normative aging to mild cognitive impairment to dementia. Additionally, a growing literature indicates that stress-related allostatic load may increase disease vulnerability. The current study examined the relationship between stress-related cytokines (ie, interleukin-6 [IL-6]), cognition as measured by Mini-Mental State Examination (MMSE) scores, and hippocampal volume. Mixed models were employed to examine both within- (across time) and between-subject effects of IL-6 and hippocampal volume on MMSE score among 566 participants from the Alzheimer's Disease Neuroimaging Initiative (ADNI). The within-subject analysis found left hippocampal volume significantly ( p = .009) predicted MMSE score. Between-subject analysis found the effect of IL-6 on MMSE was moderated by right hippocampal volume ( p = .001). These results replicate previous findings and also extend prior work demonstrating stress-related cytokines may play a role in Alzheimer's disease progression.