A New Mn(II) Complex: Magnetic Property and Application Values in Foot and Ankle Arthritis. (20th April 2022)

• Record Type: Journal Article
• Authors: Jia, Xiaochuan; Jiang, Liqiang; Cui, Shubei; Jia, Haidong
• Other Names: Caggiano Antonio Academic Editor.
• Is Part Of: International journal of polymer science. Volume 2022(2022)
• Publication Date: 2022-04-20
• Subjects: Polymers -- Periodicals; Polymers; Periodicals; 547.7
• DOI: 10.1155/2022/4609960
• Languages: English
• ISSNs: 1687-9422

Abstract

Abstract : The solvothermal reactions of C 3 -symmerical 4, 4 ′, 4 ′ -nitrilotribenzoic acid and MnCl2 afforded a novel Mn(II) compound, and its formula is [Mn3 (TCA)2 (e-urea)2 (DMA)2 ]n ·n(urea)·n(DMA) (1, H3 TCA=4, 4 ′, 4 ′ -nitrilotribenzoic acid, e-urea=2-imidazaolidone, DMA=N, N ′ -dimethylacetamide). Magnetic property investigation of 1 indicates weak antiferromagnetic mutual effects exist between neighboring Mn(II) ions. Serial biological tests were adopted to discover new compound activity. Firstly, the enzyme-linked immunosorbent assay (ELISA) was conducted to measure the content of inflammatory cytokines released into the synovial fluid. In addition, we also studied adenosine 5 ′ -monophosphate- (AMP-) activated protein kinase (AMPK) inflammatory signaling pathway activation through real-time reverse transcription-polymerase chain reaction (RT-PCR).