Healing efficacy of fracture-targeted GSK3β inhibitor-loaded micelles for improved fracture repair. (February 2017)

• Record Type: Journal Article
• Authors: Low, Stewart A; Galliford, Chris V; Jones-Hall, Yava L; Roy, Jyoti; Yang, Jiyuan; Low, Philip S; Kopeček, Jindřich
• Is Part Of: Nanomedicine. Volume 12:Number 3(2017)
• Page Start: 185
• Page End: 193
• Publication Date: 2017-02
• Subjects: bone targeting -- fracture healing -- micelles; Nanotechnology -- Periodicals; Medical technology -- Periodicals; Nanotechnology -- Therapeutic use -- Periodicals; 610.28
• DOI: 10.2217/nnm-2016-0340
• Languages: English
• ISSNs: 1743-5889

Abstract

Aim: To evaluate the fracture healing capabilities of a GSK3β inhibitor, 6-bromoindirubin-3′-oxime, coupled with an aspartic acid octapeptide in a micellar delivery system.Materials & methods: The efficacy of the intravenously administered micelles to accelerate healing of femoral fracture in mice was evaluated. Micro-computed tomography analysis was employed to obtain bone density, total volume, relative volume, trabecular thickness and trabecular spacing.Results: Both fracture bone mineral density and volume were significantly higher in the micelle treatment groups when compared with controls. The fracture-targeted micelle demonstrates fracture-specific bone anabolism and biocompatibility in off-target tissues.Conclusion: Accelerated fracture healing in mice was achieved by targeting the GSK3β inhibitor, 6-bromoindirubin-3′-oxime, to the fracture site.