Association of Sirtuin 1 Gene Polymorphisms with the Risk of Coronary Heart Disease in Chinese Han Patients with Type 2 Diabetes Mellitus. (16th April 2022)

• Record Type: Journal Article
• Authors: Wang, Yuxin; Tong, Linchao; Gu, Nan; Ma, Xiaowei; Lu, Difei; Yu, Dahong; Yu, Na; Zhang, Junqing; Li, Jianping; Guo, Xiaohui
• Other Names: Sasso Ferdinando Carlo Academic Editor.
• Is Part Of: Journal of diabetes research. Volume 2022(2022)
• Publication Date: 2022-04-16
• Subjects: Diabetes -- Periodicals; Diabetes -- Pathophysiology -- Periodicals; Diabetes -- Prevention -- Periodicals; Diabetes -- Etiology -- Periodicals; Diabetes -- Epidemiology -- Periodicals; Diabetes -- Pathogenesis -- Periodicals; 616.462005
• DOI: 10.1155/2022/8494502
• Languages: English
• ISSNs: 2314-6745

Abstract

Abstract : Aims . To explore the associations between polymorphisms in SIRT1 and coronary heart disease (CHD) risk in Chinese Han patients with type 2 diabetes (T2D). Methods . This case-controlled study enrolled 492 patients with T2D: 297 with CHD and 195 without CHD. Five SIRT1 haplotype-tagging single-nucleotide polymorphisms (rs3818291, rs12242965, rs3818292, rs4746720, and rs16924934) were selected from Chinese Han data in the GRCh37.p13 phase 3 database and genotyped by polymerase chain reaction-restriction fraction length polymorphism or sequencing. Results . The rs16924934 G allele was associated with a higher risk of CHD than the A allele (odds ratio OR = 1.429 ; 95% confidence interval CI = 1.003 – 2.037 ; P = 0.048 ). Using an additive inheritance model, the rs3818291 G/A genotype was associated with a higher CHD risk than the G/G genotype (OR ' = 1.683 ; 95 % CI = 1.033 – 2.743 ; P ' = 0.037 after adjustment for CHD risk factors). Smokers carrying G/A or A/A rs3818291 genotypes had a 3-fold higher CHD risk than those carrying GG (adjusted OR ' = 3.035 ; P ' = 0.011 ) and a 2.6-fold higher CHD risk than nonsmokers carrying GG (adjusted OR ' = 2.604 ; P ' = 0.033 ). Conclusions . Genetic polymorphisms of SIRT1 are associated with the risk of CHD in a Chinese Han population with T2D.