The role of single-nucleotide polymorphisms of the 8q24 chromosome region in patients with concomitant bladder and prostate cancer. (4th March 2022)

• Record Type: Journal Article
• Authors: Gakis, Georgios; Perner, Sven; Stenzl, Arnulf; Renninger, Markus
• Is Part Of: Scandinavian journal of urology. Volume 56:Number 2(2022)
• Page Start: 126
• Page End: 130
• Publication Date: 2022-03-04
• Subjects: Bladder cancer -- PSCA -- radical cystectomy -- recurrence -- rs2978974 -- SNP; Urology -- Periodicals; 616.6
• DOI: 10.1080/21681805.2022.2049362
• Languages: English
• ISSNs: 2168-1805

Abstract

Abstract: Objective: To assess whether single-nucleotide polymorphisms (SNPs) of the 8q24 chromosome region are associated with recurrence-free survival (RFS) after radical cystoprostatectomy (RC) in patients with concomitant bladder (BC) and prostate cancer (PC). Materials and methods: A cohort of thirty-six patients treated with RC and pelvic lymph node dissection and histologically exhibited invasive BC and incidental PC. Using Sanger sequencing, a total of seven SNPs in the androgen-responsive element of the promoter region of the following genes were assessed in tumor-free lymph nodes and correlated with oncological outcomes: PSCA (rs2294008, rs2978974, rs1045531, rs3736001), MYC (rs6983267), FXBO32 (rs7830622), and MIR151A (rs14974929). The median follow-up was 26 months (range: 4–68). Results: In a dominant model, patients exhibiting rs2978974 as a minor allelic variant of the PSCA gene had worse RFS (32 vs. 75%, p = 0.015). No associations were found for the other SNPs. Conclusions: These data suggest that the rs2978974 of the PSCA gene correlates with inferior BC-specific RFS after RC and should be further evaluated in larger studies.