Activity of chemokines in prostate and renal tumors and their potential role as future therapeutic targets. (May 2017)

• Record Type: Journal Article
• Authors: Cimadamore, Alessia; Scarpelli, Marina; Piva, Francesco; Massari, Francesco; Gasparrini, Silvia; Doria, Andrea; Cheng, Liang; Lopez-Beltran, Antonio; Montironi, Rodolfo
• Is Part Of: Future oncology. Volume 13:Number 12(2017)
• Page Start: 1105
• Page End: 1114
• Publication Date: 2017-05
• Subjects: angiogenesis -- chemokines -- prostate cancer -- renal cancer; Oncology -- Periodicals; 616.99405
• DOI: 10.2217/fon-2016-0481
• Languages: English
• ISSNs: 1479-6694

Abstract

Chemokines are a class of low-molecular-weight proteins that induce chemotaxis and are implicated in the modulation of angiogenesis. The imbalance among angiogenic and antiangiogenic chemokines can promote the development of several conditions, including chronic inflammation, dysplastic transformation and cancer. In this review, we describe the activity and clinical significance of chemokines in prostate and renal tumors and provide an update on ongoing studies in this setting.