Modeling-Based Response-Guided DAA Therapy for Chronic Hepatitis C to Identify Individuals for Shortening Treatment Duration. (22nd March 2022)

• Record Type: Journal Article
• Authors: Goyal, Ashish; Churkin, Alex; Barash, Danny; Cotler, Scott J; Shlomai, Amir; Etzion, Ohad; Dahari, Harel
• Is Part Of: Open forum infectious diseases. Volume 9:Number 5(2022)
• Publication Date: 2022-03-22
• Subjects: direct-acting antivirals -- hepatitis C virus -- mathematical modeling -- response-guided therapy -- time to cure; Communicable diseases -- Periodicals; Medical microbiology -- Periodicals; Infection -- Periodicals; 616.9
• DOI: 10.1093/ofid/ofac157
• Languages: English
• ISSNs: 2328-8957

Abstract

Abstract: Shortening duration of direct-acting antiviral therapy for chronic hepatitis C could provide cost savings, reduce medication exposure, and foster adherence and treatment completion in special populations. The current analysis indicates that measuring hepatitis C virus at baseline and on days 7 and 14 of therapy can identify patients for shortening therapy duration.