Molecular epidemiology of WU polyomavirus in hospitalized children with acute respiratory tract infection in China. (May 2017)

• Record Type: Journal Article
• Authors: Zhu, Teng; Lu, Qing-Bin; Zhang, Shu-Yan; Wo, Ying; Zhuang, Lu; Zhang, Pan-He; Zhang, Xiao-Ai; Wei, Wei; Liu, Wei
• Is Part Of: Future microbiology. Volume 12:Number 6(2017)
• Page Start: 481
• Page End: 489
• Publication Date: 2017-05
• Subjects: acute respiratory tract infection -- China -- epidemiology -- WU polyomavirus; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb-2016-0144
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: To explore the molecular epidemiology and clinical characteristics of Washington University polyomavirus (WUPyV) infection in pediatric patients with acute respiratory tract infections in China.Materials & methods: A laboratory surveillance was performed to recruit pediatric patients with acute respiratory tract infections. WUPyV was detected using real-time PCR and complete genome was sequenced for randomly selected positive nasopharyngeal aspirate.Results: Altogether 122 (7.5%) of 1617 children found to be infected with WUPyV and 88 (72.1%) were coinfected with other viruses during 2012–2015. The phylogenetic analysis showed that 14 strains from our study formed two new clusters (Id and IIIc) within the Branch I and Branch III, respectively.Conclusion: WUPyV is persistently circulating in China. Surveillance on WUPyV infection in wider areas and long persistence is warranted.