Clinical and molecular epidemiology of Acinetobacter baumannii bloodstream infections in an endemic setting. (March 2017)

• Record Type: Journal Article
• Authors: Marchaim, Dror; Levit, Dana; Zigron, Roy; Gordon, Michal; Lazarovitch, Tsillia; Carrico, Joao A; Chalifa-Caspi, Vered; Moran-Gilad, Jacob
• Is Part Of: Future microbiology. Volume 12:Number 4(2017)
• Page Start: 271
• Page End: 283
• Publication Date: 2017-03
• Subjects: carbapenem -- Gram-negative -- MDR -- MLST -- nonfermenter -- nosocomial infections -- typing; Microbiology -- Research -- Periodicals; 616.9041
• DOI: 10.2217/fmb-2016-0158
• Languages: English
• ISSNs: 1746-0913

Abstract

Aim: The transmission dynamics of Acinetobacter baumannii in endemic settings, and the relation between microbial properties and patients' clinical outcomes, are yet obscure and hampered by insufficient metadata.Methods & Results: Of 20 consecutive patients with A. baumannii bloodstream infection that were thoroughly analyzed at a single center, at least one transmission opportunity was evident for 85% of patients. This implies that patient-to-patient transmission is the major mode of A. baumannii acquisitions in health facilities. Moreover, all patients who died immediately (<24 h of admission) were infected with a single clone (ST457; relative risk = 1.6; p = 0.05).Conclusion: This preliminary analysis should prompt further investigation by mapping genomic virulence determinants among A. baumannii ST457 lineage compared with other strains.