Aging, exceptional longevity and comparisons of the Hannum and Horvath epigenetic clocks. (May 2017)

• Record Type: Journal Article
• Authors: Armstrong, Nicola J; Mather, Karen A; Thalamuthu, Anbupalam; Wright, Margaret J; Trollor, Julian N; Ames, David; Brodaty, Henry; Schofield, Peter R; Sachdev, Perminder S; Kwok, John B
• Is Part Of: Epigenomics. Volume 9:Number 5(2017)
• Page Start: 689
• Page End: 700
• Publication Date: 2017-05
• Subjects: acceleration -- age -- aging -- centenarians -- DNAmage -- epigenetic clock -- longevity; Epigenesis -- Periodicals; Genomics -- Periodicals; Chromatin -- Periodicals; DNA -- Periodicals; 572.87
• DOI: 10.2217/epi-2016-0179
• Languages: English
• ISSNs: 1750-1911

Abstract

Aim: To examine the relationships between two epigenetic clocks, aging and exceptional longevity.Materials & methods: Participants were from three adult cohorts with blood DNA methylation data (Illumina 450 K, n = 275, 34–103 years). Epigenetic age (DNAmage) and age acceleration measures were calculated using the Hannum and Horvath epigenetic clocks.Results: Across all cohorts, DNAmage was correlated with chronological age. In the long-lived cohort (Sydney Centenarian Study; 95+, n = 23), DNAmage was lower than chronological age for both clocks. Mean Sydney Centenarian Study Hannum age acceleration was negative, while the converse was observed for the Horvath model.Conclusion: Long-lived individuals have a young epigenetic age compared with their chronological age.